T. Agarkova, K. Kublinskiy, I. Evtushenko, I. Naslednikova, V. Tkachev, V. Novitskiy, M. Skorohodova


The clinical and molecular-genetic examinations and therapy of 150 patients, suffering from infertility, with genital endometriosis were carried out by the medical team. The complex treatment included surgical laparoscopic method and hormonal agents (agonists of gonadrophin-releasing-hormones, combined oral contraceptives.) The low effectiveness of the infertility therapy, associated with endometriosis, relates to the carriage of risky genotypes: AA and GA polymorphism G-308A of TNFA gene.


Ключевые слова

infertility; genital endometriosis; therapy; tumor-alpha necrosis factor; transforming growth-beta factor; polymorphism of cytokine genes

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Adamyan L.V., Kulakov V.I., Andreeve E.N. Endometriosis. – M., Medicine. 2006.-p.416.

Gerasimov A.M. Infertility etiology with external endometriosis// Vestnikakush.gin. – 2008.– №1. – p. 31-35.

Krutova V.A., Galustyan S.A., Belkina N.V. Complex therapy of women with infertility, associated with genital endometriosis// Vestnik akush. gin. – 2008. – №2. – p. 46-49.

Ischenko A.I., Kudrina E.A. Endometriosis: diagnose and therapy. – М.:МIA. 2008. – p. 176.

Simbirtsev A.S., Gromova A.U. Functional genes’ polymorphism of regulatory in flammation molecules // Immunology. – 2005. – №1. – p.67-72.

Allaire C. Endometriosis and infertility: a review // J. Reprod. Med. – 2006. – V.51.№3. – Р. 164-168.

Campo S., Campo V., Benagiano G. Infertility and adenomyosis // Obstet. Gynecol. Int. – 2012. – V.78.№12. – Р. 956-960.

Harada T., Iwabe T., Terakawa N. Role of cytokines in endometriosis // Fertil. Steril. – 2001. – V.76.№1. – Р. 1-10.

Iwabe T., Harada T., Terakawa N. Role of cytokines in endometriosis-associated infertility // Gynec. Obstet. Invest. – 2002. – V.53.№1. – Р. 19-25.

Senapati S., Barnhart K. Managing endometriosis-associated infertility // Clin. Obstet. Gynecol. – 2011. – V.54.№4. – Р. 720-726.

Stilley J.A., Birt J.A., Sharpe-Timms K.L. Cellular and molecular basis for endometriosis-associated infertility // Cell Tissue Res. – 2012. – V.3.№1. – Р. 44-49.


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(c) 2016 International Journal of Advanced Studies

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ISSN 2328-1391 (print), ISSN 2227-930X (online)