МОЖЕТ ЛИ МЕЛАТОНИН ЭФФЕКТИВНО ИСПОЛЬЗОВАТЬСЯ ДЛЯ КОРРЕКЦИИ ПОБОЧНЫХ ЭФФЕКТОВ РАЗЛИЧНЫХ ПСИХОТРОПНЫХ ЛЕКАРСТВ И ЭЛЕКТРОСУДОРОЖНОЙ ТЕРАПИИ?

Roman Aleksandrovich Bekker, Angelina Nailevna Hannanova, Yuriy Vitalevich Bykov


Аннотация


Цель исследования. Изучить и обобщить имеющуюся доказательную базу для применения мелатонина в качестве корректора побочных эффектов психотропных лекарств и электросудорожной терапии, и представить читателю соответствующие выводы.

Методология проведения работы. Авторами был проведён поиск литературы о применении мелатонина в качестве корректора побочных эффектов психотропных лекарств и электросудорожной терапии в PubMed и Google Scholar. Найденные в результате этого поиска литературные данные представлены в настоящей статье.

Результаты. Полученные нами в результате данного обзора литературы данные свидетельствуют о том, что мелатонин может быть эффективно использован как в монотерапии, так и в комбинации с другими корректорами с целью уменьшения ряда побочных эффектов психотропных лекарств и электросудорожной терапии, и заслуживает дальнейшего изучения в этом качестве. Доказательная база по его применению различна для различных побочных эффектов. Наибольшая доказательная база имеется об эффективности применения мелатонина в предотвращении и лечении диссомнических нарушений, нарушений памяти и когнитивных функций, акатизии, поздних дискинезий, а также метаболического синдрома.

Область применения результатов. Полученные нами результаты могут применяться в психиатрии, неврологии и наркологии, а также во всех тех областях общесоматической медицины, в которых находят своё применение психотропные препараты.


Ключевые слова


мелатонин; лекарственная инсомния; поздние дискинезии; акатизия; метаболический синдром; антипсихотики; антидепрессанты; электросудорожная терапия; побочные эффекты; эпифиз

Полный текст:

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Литература


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DOI: https://doi.org/10.12731/wsd-2017-4-174-204

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