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НОВЫЙ ТИП ТЕРМОГЕННЫХ АДИПОЦИТОВ: ПРОИСХОЖДЕНИЕ, СВОЙСТВА, ФУНКЦИИ
Аннотация
Термогенез в жировых тканях рассматривается как потенциальная мишень в терапии ожирения и метаболического синдрома. Молекулярные механизмы, регуляция термогенеза детально изучены в бурой жировой ткани. Целью данного обзора является систематизация сведений о новом типе термогенных адипоцитов, обнаруживаемых в депо белого жира.
Особенности морфологии, биохимии, предполагаемое онтогенетическое происхождение этих клеток, факторы, поддерживающие процессы их дифференцировки во взрослом организме, рассматриваются в сравнении с типичными бурыми и белыми адипоцитами. Приведены сведения об их анатомической локализации и термогенном потенциале у человека. Эволюционное появление двух типов термогенных клеток с разной степенью пластичности, во-первых, расширило диапазон термогенных реакций, во-вторых, способствовало более экономному использованию энергосубстратов для целей терморегуляции. Суммарный вклад термогенных адипоцитов нового типа в энергообмен человека и животных, возможные регуляторные функции этих клеток требуют дальнейших исследований.
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Литература
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DOI: https://doi.org/10.12731/wsd-2016-8-97-127
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