IMMUNE-GENETICS МARKERS OF GENITAL ENDOMETRIOSIS

N. Menshikova, K. Kublinskiy, T. Agarkova, I. Evtushenko, V. Novitskiy, V. Tkachev, I. Naslednikova


Аннотация


Modern molecular genetic methods have helped to reveal immune-genetic markers of genital endometriosis. It was shown, that susceptibility to endometriosis is positively associated with the genotypes СС and СА the promoter region С-592A of the gene IL10 and with the genotype АА polymorphism A1188C of the gene IL12. It was proved that the immune-genetic factors with protective effect against endometriosis are the polymorphism С-592A genotype АА of the gene IL10 and the genotype СС from polymorphism A1188C of the gene IL12.

DOI: http://dx.doi.org/10.12731/2227-930X-2012-1-14


Ключевые слова


genital endometriosis; cytokine genes’ allelic polymorphism; interleykine-10; interleykine-12

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Литература


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(c) 2016 International Journal of Advanced Studies



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ISSN 2328-1391 (print), ISSN 2227-930X (online)