«ВЕРБЛЮЖЬИ» АНТИТЕЛА: ОСОБЕННОСТИ ИХ СТРОЕНИЯ, ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ

Alexey Alekseevich Andreev, Nadezhda Petrovna Lopina, Galina Evgenievna Bordina, Elizaveta Georgievna Nekrasova


Аннотация


В статье представлен аналитический обзор научной литературы на тему «верблюжьих» антител, их открытия, структурных отличий от классических иммуноглобулинов и их применения в генной инженерии, биологических исследованиях и в медицине, в частности, в онкологической терапии.

 


Ключевые слова


«верблюжьи» антитела; иммуноглобулины; нанотела; моноклональные антитела; наноантитела; мини-антитела; однодоменные антитела; фаговый дисплей

Полный текст:

PDF>PDF

Литература


Tillib S.V. Molekulyarnaya biologiya. 2011. V. 45. № 1, рр. 77–85.

Novikov V.V., Pimenov V.K., Vyaz’mina E.S. et al. Vestnik Nizhegorodskogo universiteta im. N. I. Lobachevskogo. Seriya: Biologiya. 1999. № 1, рр. 143–147.

Royt A., Brostoff Dzh., Meyl D. Immunologiya [Immunology]. M.: Mir, 2000.

Gusel’nikova V.V., Korzhevskiy D.E. NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker. Acta Naturae. 2015. Vol. 7, No. 2 (25), pp. 42–47.

Sedykh S.E., Nevinskiy G.A. Uspekhi molekulyarnoy onkologii. 2018. V. 5. № 2, рр. 30–40.

Dorokhov Y.L., Sheshukova E.V., Kosobokova E.N. et al. Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies. Biochemistry (Moscow). 2016. Vol. 81, No. 8, pp. 835–857.

Sakovich A.R. Profil’ immunoglobulinov u patsientov s ostrym sinusitom. Otorinolaringologiya. Vostochnaya Evropa. 2014. № 1 (14), рр. 46–51.

Seleznev S.B. Niva Povolzh’ya. 2008. № 1 (6), рр. 59–64.

Gorshkova E.N., Vasilenko E.A., Tillib S.V. et al. Meditsinskaya immunologiya. 2016. V. 18. № 6, рр. 505–520.

Garas M.N., Tillib S.V., Zubkova O.V. et al. Construction of a pIX-modified Adenovirus Vector Able to Effectively Bind to Nanoantibodies for Targeting. Acta Naturae. 2014. Vol. 6, No. 2 (21), pp. 95–105.

Gladyshev P.P., Vasil’ev A.A., Morenkov O.S. et al. Sovremennaya meditsina: aktual’nye voprosy. 2016. № 51, рр. 22–48.

Dormeshkin D.O., Brichko E.A., Gilep A.A. et al. Proceedings of the National Academy of Sciences of Belarus, Chemical series. 2017. № 2, рр. 93–110.

Lushova A.A., Byazrova M.G., Prilipov A.G. et al. Molekulyarnaya biologiya. 2017. V. 51, № 6, рр. 899–906.

Karabelskii A.V., Nemankin T.A., Ulitin A.B. et al. Design of innovate preparations of monoclonal antibodies. Biotechnology in Russia. 2017. No. 1, pp. 10–29.

Danilov S.M. Molekulyarnaya biologiya. 2017. V. 51. № 6, рр. 1046–1061.

Kuklina G.V., Elagin G.D., Fomenkov O.O. et al. Problemy osobo opasnykh infektsiy. 2017. № 2, рр. 67–71.

Nemudraya A.A., Richter V.A., Kuligina E.V. Phage Peptide Libraries As a Source of Targeted Ligands. Acta Naturae. 2016. Vol. 8, No. 1 (28), pp. 48–57.

Ledeboer A.M., Besemer S., J.J.W. de Haard et al. Preventing Phage Lysis of Lactococcus lactis in Cheese Production Using A Neutralizing Heavy-Chain Anti-body Fragment from Llama. Journal of Dairy Science. 2002. Vol. 85, No. 6, pp. 1376–1382.

Deyev S.M., Polianovskii O.L. Monoclonal Antibodies for Diagnostics and Therapy. Biotechnology in Russia. 2008. No. 2, pp. 1–15.

Deyev S.M., Lebedenko E.N. Modern Technologies for Creating Synthetic Antibodies for Clinical Application. Acta Naturae. 2009. Vol. 1, No. 1 (1), pp. 32–50.

Osipova I. G., Vaganova O. A., Sakanyan E. I. Actual Problems in Standardization in RF of Biotechnological Medicinal Products on the basis of Monoclonal Antibodies. Biotechnology in Russia. 2017. No. 1, pp. 80–90.

Deyev S.M., Lebedenko E.N., Petrovskaya L.E. et al. Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering. Russian chemical reviews. 2015. Vol. 84, No. 1, pp. 1–26.

Kravchenko Y.E., Ivanov S.V., Kravchenko D.C. et al. Combination of ribo-some and phage display for fast selection of high affinity VHH antibody fragments. Bulletin of Russian State Medical University. 2019. No. 1, pp. 27–33.

Tillib S.V., Ivanova T.I., Vasilev L.A. Fingerprint-like Analysis of “Nanoantibody” Se-lection by Phage Display Using Two Helper Phage Variants. Acta Naturae. 2010. Vol. 2, No. 3 (6), pp. 85–93.

Tillib S.V. Allergologiya i immunologiya. 2016. V. 17. № 1, рр. 27–29.

Vyatchanin A.S., Tillib S.V. Modifications in the Phage Display Procedure to Increase Selection Efficiency of Antigen-Binding Domains on Distinguished Single-Chain Camel Antibodies. Biotechnology in Russia. 2008. No. 4, pp. 30–38.

Tillib S.V., Efimov G.A., Gubernatorova E.O. et al. Rossiyskiy immunologicheskiy zhurnal. 2015. V. 9 (18). № 2, рр. 93–110.

Klooster R., Maassen B.T.H., Stam J.C. et al. Improved anti-IgG and HSA affinity ligands: Clinical application of VHH antibody technology. Journal of Immunological Methods. 2007. Vol. 324, No. 1-2, pp. 1–12.

Syrova N.A., Terekhova I.V., Tereshkina N.E. et al. Culturing of Hybridomas Producing Diagnostically Significant Monoclonal Antibodies to Francisella tularensis. Biotechnology in Russia. 2012. No. 2, pp. 66–72.

Gribova I.Yu., Tillib S.V., Tutikhina I.L. et al. Effective Genetic Expression of Nanoantibodies by Recombinant Adenoviral Vector in vitro. Acta Naturae. 2011. Vol. 3, No. 3 (10), pp. 64–70.




DOI: https://doi.org/10.12731/2658-6649-2020-12-2-25-40

Ссылки

  • На текущий момент ссылки отсутствуют.




(c) 2020 Alexey Alekseevich Andreev, Nadezhda Petrovna Lopina, Galina Evgenievna Bordina, Elizaveta Georgievna Nekrasova

Лицензия Creative Commons
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.

ISSN 2658-6649 (print)

ISSN 2658-6657 (online)

HotLog Яндекс цитирования