О РОЛИ ИММУНОЛОГИЧЕСКИХ НАРУШЕНИЙ В ПАТОГЕНЕЗЕ КОГНИТИВНОЙ ДИСФУНКЦИИ ПРИ ДЕПРЕССИВНЫХ СОСТОЯНИЯХ. ЧАСТЬ I. (ОБЗОР ЛИТЕРАТУРЫ С КОММЕНТАРИЯМИ)

Roman Aleksandrovich Bekker, Yuriy Vitalevich Bykov


Аннотация


Депрессивные состояния часто сопровождаются гиперактивностью оси гипоталамус–гипофиз–надпочечники и гиперкортизолемией и как следствие атрофией тимуса, снижением секреции тимусных гормонов и снижением иммунитета, или бывают коморбидны с инфекционными, воспалительными, аутоиммунными заболеваниями. В то же время депрессии часто сопровождаются развитием когнитивных нарушений, причём показано, что именно выраженность когнитивных нарушений в наибольшей степени определяет функциональные исходы и возможность социализации больных с депрессиями. С другой стороны, известно, что удаление тимуса или селезёнки часто сопровождается развитием депрессии и когнитивных нарушений, а применение иммуностимуляторов может оказывать положительное действие как на депрессию, так и на параметры когнитивного функционирования. В данной статье рассматривается вопрос о влиянии иммунологических нарушений на параметры когнитивного функционирования депрессивных больных и имеющаяся доказательная база для применения методов иммунной коррекции когнитивных нарушений при депрессивных состояниях, даются общего характера практические рекомендации по применению некоторых из них.

Ключевые слова


депрессивные состояния; когнитивные нарушения; иммунологические нарушения; тимэктомия; спленэктомия; тималин; тактивин; тимоген; спленин; деринат; прополис; дибазол; левамизол

Полный текст:

PDF>PDF

Литература


Беккер Р.А., Быков Ю.В. Когнитивные нарушения при депрессиях: клиническое значение и современные возможности терапии. Психиатрия и психофармакотерапия им. П.Б. Ганнушкина. 2015; 04: 40–45.

Быков Ю.В., Беккер Р.А., Резников М.К. Депрессии и резистентность. М.: ИНФРА–М, 2013. 374 с.

Мазо Г.Э., Незнанов Н.Г. Терапевтически резистентные депрессии. Санкт-Петербург, Береста, 2012. 448 c.

Обухов С.Г. Психиатрия / Под ред. Ю.А. Александровского. М.: ГЭОТАР–Медиа, 2007. 352 с.

Abatnina Iu.V., Bazhanova E.D., Teplyĭ D.L. [Hypothalamic neurosecretory cell apoptosis during stress in mice at different stages of ontogenesis]. [Article in Russian]. Morfologiia. 2005; 127(3): 27–29.

Abatnina Y.V., Bazhanova E.D., Teplyi D.L. Apoptosis of hypothalamic neurosecretory cells in stress mice at different stages of ontogenesis. Neurosci Behav Physiol. 2006; 36(5): 527–530.

Abdulmajeed W.I., Sulieman H.B., Zubayr M.O. et al. Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male Wistar rats – a preliminary study. Metab Brain Dis. 2016; 31(1): 37–44.

Aleksandrovskiĭ Iu.A., Chekhonin V.P. [Clinical and immunological studies in borderline mental disorders: problems and solutions]. [Article in Russian]. Vestn Ross Akad Med Nauk. 1999; (7): 12–25.

Azman K.F., Zakaria R., AbdAziz C. et al. Tualang honey improves memory performance and decreases depressive–like behavior in rats exposed to loud noise stress. Noise Health. 2015; 17(75): 83–89.

Bazhanova E.D. [Apoptosis of the hypothalamus neurosecretory cells in stress and ageing: the role of immune modulators]. [Article in Russian]. Ross Fiziol Zh Im I M Sechenova. 2012; 98(4): 542–550.

Bazhanova E.D. [Cycloferon: mechanism of action, functions and application]. [Article in Russian]. Eksp Klin Farmakol. 2012; 75(7): 40–44.

Bazhanova E.D. [Role of cycloferon and interferon–alphain apoptosis regulation in neuroendocrinal system on aging]. [Article in Russian]. Eksp Klin Farmakol. 2012; 75(10): 42–46.

Canli T. Reconceptualizing major depressive disorder as an infectious disease. Biol Mood Anxiety Disord. 2014, Oct 21; 4:10.

Catanzaro R., Anzalone M., Calabrese F. et al. The gut microbiota and its correlations with the central nervous system disorders. Panminerva Med. 2015; 57(3): 127–143.

Chaurasiya N.D., Ibrahim M.A., Muhammad I. et al. Monoamine oxidase inhibitory constituents of propolis: kinetics and mechanism of inhibition of recombinant human MAO–A and MAO–B. Molecules. 2014, Nov 18; 19(11): 18936–18952.

Chen S.Y., Lin J.R., Kao M.D. et al. Dietary supplement usage among elementary school children in Taiwan: their school performance and emotional status. Asia Pac J Clin Nutr. 2007; 16 Suppl 2: 554–563.

Cordero O.J., Piсeiro A., Nogueira M. Thymic peptides and preparations: an update. Arch Immunol Ther Exp (Warsz). 1999; 47(2): 77–82.

Doroshenko N.M., Korpachev V.V. [Role of the spleen in the regulation of the calcium content of the blood plasma in health and in stress]. [Article in Russian]. Fiziol Zh. 1989; 35(1): 17–21.

El–Abbadi N.H., Dao M.C., Meydani S.N. Yogurt: role in healthy and active aging. Am J Clin Nutr. 2014; 99(5 Suppl): 1263S–70S.

Fomicheva E.E., Filatenkova T.A., Shanin S.N. et al. Stress–induced changes in the functional activity of the neuroendocrine system: the modulatory activity of derinat. Neurosci Behav Physiol. 2010 May; 40(4): 397–401.

Gareau M.G. Microbiota–gut–brain axis and cognitive function. Adv Exp Med Biol. 2014; 817: 357–371.

Gasanov S.G., Buianovskaia O.A., Nechaeva E.B. et al. [Effect of splenin and its fractions on the functional state of the adrenal cortex]. [Article in Russian]. Biull Eksp Biol Med. 1981; 92(7): 98–100.

Grechko A.T. [The neurotropic activity of peptide immunomodulators]. [Article in Russian]. Eksp Klin Farmakol. 1998; 61(4): 14–16.

Guang H.M., Du G.H. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Eur J Pharmacol. 2006; 542(1–3): 77–83.

Kennedy P.J., Cryan J.F., Dinan T.G. et al. Irritable bowel syndrome: a microbiome–gut–brain axis disorder? World J Gastroenterol. 2014; 20(39): 14105–14125.

Kiseleva N.M., Novoseletskaya A.V., Voevodina Y.B. et al. Quantitative evaluation of learning and memory trace in studies of mnemotropic effects of immunotropic drugs. Bull Exp Biol Med. 2012; 154(2): 233–236.

Komissarenko V.P. [Therapy of early toxicosis (vomiting) in pregnancy with splenin]. [Article in Russian]. Akush Ginekol (Mosk). 1959; 35: 46–48.

Korpachev V.V., Shostak I.N. [The effect of biologically active substances from the spleen on the content of somatotropic hormone in the rat hypophysis]. [Article in Russian]. Probl Endokrinol (Mosk). 1990; 36(5): 82–85.

Kunz E., Bьhler J., Gmцhling M. et al. [Subjective sequelae of splenectomy]. [Article in German]. Langenbecks Arch Chir. 1990; 375(4): 214–219.

Kunz E., Gunzer U., Haubitz I. [The risk of splenectomy]. [Article in German]. Med Klin (Munich). 1994; 89(10): 515–521.

Kut’ko I.I., Tereshina I.F. [Effect of immunomodulatory therapy on circulatory immune complexes in patients with recurrent depressive disorders]. [Article in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova. 2014; 114(3): 41–45.

Lazarev N.V., Rozin M.A. [Dibasol in diseases of the nervous system].[Article in Russian]. Sov Med. 1951; 4: 24–26.

Lee M.S., Kim Y.H., Park W.S. et al. Novel antidepressant–like activity of propolis extract mediated by enhanced glucocorticoid receptor function in the hippocampus. Evid Based Complement Alternat Med. 2013; 2013: 217853.

Liu R., Wu C.X., Zhou D. et al. Pinocembrin protects against β–amyloid–induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)–independent signaling pathways and regulating mitochondrion–mediated apoptosis. BMC Med. 2012; 10: 105.

Luo J., Wang T., Liang S. et al. Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.Sci China Life Sci. 2014; 57(3): 327–35.

Maruta N.A., Rachkauskas G.S., Frolov V.M. et al. [Efficacy of the combination of cycloferon and reamberin in treatment of resistant patients with paranoid schizophrenia]. [Article in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova. 2011; 111(12): 36–39.

Melekhin V.D., Pleskovskaia G.N., Leshchenko G.Ia. et al. [Characteristics of memory in MRL/1 mice and the effect of thymic peptides]. [Article in Russian]. Biull Eksp Biol Med. 1989; 107(2): 199–201.

Mikhaĭlova A.A. [Myelopeptides as a new group of regulatory peptides].[Article in Russian]. Vestn Ross Akad Med Nauk. 1999; (4): 49–52.

Miniello S., Testini M., Jirillo E. et al. Postsplenectomy immunodepression and its implications: an underestimated problem. Int Surg. 2002; 87(4): 245–251.

Miyazaki Y., Sugimoto Y., Fujita A. et al. Ethanol extract of Brazilian propolis ameliorates cognitive dysfunction and suppressed protein aggregations caused by hyperhomocysteinemia. Biosci Biotechnol Biochem. 2015; 79(11): 1884–1889.

Musienko G.V. [Thymalin in the combined treatment of parkinsonism patients]. [Article in Russian]. Lik Sprava. 1999; (1): 119–122.

Nasolodin V.V., Rusin V.Ia., Voronin S.M. [Hygienic evaluation of supplementary administration of trace elements, vitamin C and dibasol to the nutrition rations of sportsmen]. [Article in Russian]. Gig Sanit. 1989; (7): 83–84.

Nevidimova T.I., Suslov N.I. [The psychotropic effects of thymogen]. [Article in Russian]. Biull Eksp Biol Med. 1995; 119(2): 199–200.

Nishiyama N. Thymectomy–induced deterioration of learning and memory. Cell Mol Biol (Noisy–le–grand). 2001; 47(1): 161–165.

Petrunia A.M., Enenko Iu.A. [The efficacy of immunomodulating therapy in patients with chronic cholestatic liver diseases]. [Article in Russian]. Lik Sprava. 1996; (3–4): 125–127.

Podsevatkin V.G., Kiriukhina S.V., Podsevatkin D.V. et al. [Dynamics of the behavioral response and cortisole level caused by the combined action of mexidole, diazepam, thymogen, and hyperbaric oxygenation in mice under immobilization stress conditions]. [Article in Russian]. Eksp Klin Farmakol. 2008; 71(1): 22–25.

Reis J.S., Oliveira G.B., Monteiro M.C. et al. Antidepressant–and anxiolytic–like activities of an oil extract of propolis in rats. Phytomedicine. 2014; 21(11): 1466–1472.

Saito H., Nishiyama N., Zhang Y. et al. Learning disorders in thymectomized mice: a new screening model for cognitive enhancer. Behav Brain Res. 1997; 83(1–2): 63–69.

Starikov A.S., Kasumova T.T. [The immune response to brain contusion with hematoma–induced compression]. [Article in Russian]. Zh Vopr Neirokhir Im N N Burdenko. 1997; (4): 16–18.

Steenbergen L., Sellaro R., van Hemert S. et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015; 48: 258–264.

Triumfov A.V. [Results of dibasol therapy of certain diseases of the nervous system]. [Article in Russian]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1952; 52(4): 37–38.

Tsai C.F., Kuo Y.H., Yeh W.L. et al. Regulatory effects of caffeic acid phenethyl ester on neuroinflammation in microglial cells. Int J Mol Sci. 2015; 16(3): 5572–5589.




DOI: https://doi.org/10.12731/wsd-2016-8-40-62

Ссылки

  • На текущий момент ссылки отсутствуют.


Bookmark and Share


(c) 2016 В мире научных открытий



ISSN 2658-6649 (print)

ISSN 2658-6657 (online)

HotLog Яндекс цитирования